2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W096116
    PEG2-Cl 78925-46-9
    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG2-Cl
  • HY-138517
    Thiol-C9-PEG7 130727-44-5
    Thiol-C9-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C9-PEG7
  • HY-140455
    Azido-PEG10-acid 1644163-57-4
    Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-acid
  • HY-130674
    Tos-PEG3-CH2COOH 1581248-63-6
    Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG3-CH2COOH
  • HY-141246
    1-Isothiocyanato-PEG4-alcohol 1835759-69-7
    1-Isothiocyanato-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1-Isothiocyanato-PEG4-alcohol
  • HY-140293
    DBCO-NH-Boc 1539290-74-8
    DBCO-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NH-Boc
  • HY-143836
    Acid-PEG10-t-butyl ester
    Acid-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG10-t-butyl ester
  • HY-140960
    DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside, MW 2000
    DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside, MW 2000
  • HY-132095
    Methyl-PEG4-acyl chloride 62124-69-0
    Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG4-acyl chloride
  • HY-138515
    Br-PEG7-NHBoc 2688072-18-4
    Br-PEG7-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG7-NHBoc
  • HY-141003
    3,4-Dibromo-Mal-PEG8-acid
    3,4-Dibromo-Mal-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,4-Dibromo-Mal-PEG8-acid
  • HY-121507
    Hydroxy-PEG2-C2-sulfonic acid 112724-27-3
    Hydroxy-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-C2-sulfonic acid
  • HY-111456
    DBCO-NHCO-PEG4-NHS ester 2100306-58-7
    DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG4-NHS ester
  • HY-140965
    Mal-PEG5-Boc 2250216-91-0
    Mal-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG5-Boc
  • HY-140029
    Propargyl-PEG10-Boc 2055022-22-3
    Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG10-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG10-Boc
  • HY-141332
    Lipoamido-PEG4-acid 1314378-10-3
    Lipoamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Lipoamido-PEG4-acid
  • HY-140867
    N-(Azido-PEG2)-N-bis(PEG4-Boc) 2112731-81-2
    N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-bis(PEG4-Boc)
  • HY-140842
    Azido-PEG4-nitrile 2194563-82-9
    Azido-PEG4-nitrile is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-nitrile is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-nitrile
  • HY-132053
    Benzyl-PEG16-alcohol
    Benzyl-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG16-alcohol
  • HY-140979
    Mal-amido-PEG8-TFP ester 1924596-31-5
    Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG8-TFP ester
PROTAC Linkers Isoform Comparison

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